Item Type | Name |
Academic Article
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Complex regulation of CDK2 during phorbol ester-induced hematopoietic differentiation.
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Academic Article
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Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells.
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Academic Article
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Regulation of the p58GTA cell division control-related protein kinase during phorbol 12-myristate 13-acetate-induced terminal differentiation of U937 cells.
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Academic Article
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Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA-binding protein.
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Academic Article
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Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase.
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Academic Article
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In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
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Academic Article
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Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis.
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Academic Article
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Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation.
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Academic Article
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Bax-induced apoptotic cell death.
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Academic Article
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Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit mediate activation of Jak/Stat signaling and differentiation.
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Academic Article
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Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells.
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Academic Article
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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway.
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Academic Article
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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.
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Academic Article
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Overexpression of the oncogenic kinase Pim-1 leads to genomic instability.
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Academic Article
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Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor.
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Academic Article
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Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation.
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Academic Article
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The role of the Smad3 protein in phorbol ester-induced promoter expression.
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Academic Article
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The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.
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Academic Article
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Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.
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Academic Article
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AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.
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Academic Article
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Regulation of RUNX1/AML1 during the G2/M transition.
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Academic Article
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The human brm protein is cleaved during apoptosis: the role of cathepsin G.
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Academic Article
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Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.
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Academic Article
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Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells.
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Academic Article
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A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.
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Academic Article
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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.
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Academic Article
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells.
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Academic Article
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Overexpression of protein kinase C beta 1 is not sufficient to induce factor independence in the interleukin-3-dependent myeloid cell line FDC-P1.
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Academic Article
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The Pim protein kinases regulate energy metabolism and cell growth.
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Academic Article
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Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.
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Academic Article
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Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer.
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Academic Article
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Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.
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Academic Article
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Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial.
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Academic Article
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Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.
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Academic Article
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Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.
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Academic Article
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Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.
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Academic Article
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Varied differentiation responses of human leukemias to bryostatin 1.
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Academic Article
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The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells.
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Academic Article
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Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.
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Academic Article
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Signal transduction by a CD16/CD7/Jak2 fusion protein.
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Academic Article
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Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.
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Academic Article
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Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2.
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Academic Article
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Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.
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Academic Article
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Mapping the intracytoplasmic regions of the alpha granulocyte-macrophage colony-stimulating factor receptor necessary for cell growth regulation.
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Academic Article
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A critical role for the cytoplasmic domain of the granulocyte-macrophage colony-stimulating factor alpha receptor in mediating cell growth.
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Academic Article
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Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells.
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Academic Article
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Phosphorylation of transcription factors.
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Academic Article
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Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C.
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Academic Article
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The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells.
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Academic Article
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Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells.
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Academic Article
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The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.
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Academic Article
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Pim family kinases enhance tumor growth of prostate cancer cells.
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Academic Article
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ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.
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Academic Article
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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
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Academic Article
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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
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Academic Article
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p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.
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Academic Article
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Regulation of Skp2 levels by the Pim-1 protein kinase.
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Academic Article
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The BH3 mimetic ABT-737 induces cancer cell senescence.
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Academic Article
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Lack of phosphorylation of lipocortin I in A431 epidermoid carcinoma cells treated with phorbol esters.
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Academic Article
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Interleukin-3 and bryostatin 1 mediate rapid nuclear envelope protein phosphorylation in growth factor-dependent FDC-P1 hematopoietic cells. A possible role for nuclear protein kinase C.
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Academic Article
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A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy.
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Academic Article
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Tyrosine kinase and phosphotyrosine phosphatase activity in human promyelocytic leukemia cells and human polymorphonuclear leukocytes.
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Academic Article
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Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60).
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Academic Article
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Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.
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Academic Article
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Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor.
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Academic Article
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The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.
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Academic Article
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In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.
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Academic Article
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Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.
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Academic Article
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A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase.
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Academic Article
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Multiple signal transduction pathways mediate c-Jun protein phosphorylation.
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Academic Article
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Regulation of jun/AP-1 oncoproteins by protein phosphorylation.
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Academic Article
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In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity.
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Academic Article
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Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.
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Academic Article
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Biological activity of 26-succinylbryostatin 1.
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Academic Article
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Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
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Academic Article
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Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
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Academic Article
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The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation.
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Concept
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Protein-Tyrosine Kinases
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Concept
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Protein Binding
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Protein Phosphatase 1
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Concept
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Protein Processing, Post-Translational
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Concept
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Tumor Suppressor Protein p53
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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p38 Mitogen-Activated Protein Kinases
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Concept
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Mitogen-Activated Protein Kinase Kinases
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Concept
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Protein Tyrosine Phosphatase, Non-Receptor Type 6
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Concept
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Protein Kinase Inhibitors
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Concept
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Ribosomal Protein S6 Kinases
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Concept
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Protein Phosphatase 2
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Concept
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Glial Fibrillary Acidic Protein
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Concept
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Mitogen-Activated Protein Kinase 1
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Concept
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Protein Biosynthesis
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Concept
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CDC2 Protein Kinase
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Concept
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Protein Kinases
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Concept
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bcl-2-Associated X Protein
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Concept
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Concept
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Protein Synthesis Inhibitors
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Concept
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CASP8 and FADD-Like Apoptosis Regulating Protein
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Concept
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Mitogen-Activated Protein Kinase 3
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Concept
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bcl-Associated Death Protein
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Concept
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Fas-Associated Death Domain Protein
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Concept
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TATA-Box Binding Protein
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Protein Kinase C
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Concept
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Protein Structure, Tertiary
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Concept
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Ubiquitin-Protein Ligase Complexes
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Concept
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Receptor Protein-Tyrosine Kinases
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Concept
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Smad3 Protein
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Concept
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Protein Stability
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Concept
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Protein Tyrosine Phosphatases
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Concept
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Amyloid Precursor Protein Secretases
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Concept
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Fas Ligand Protein
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Concept
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JNK Mitogen-Activated Protein Kinases
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Concept
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bcl-X Protein
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Concept
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Mitogen-Activated Protein Kinase 10
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Concept
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Protein Isoforms
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Concept
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Protein Conformation
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Concept
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Von Hippel-Lindau Tumor Suppressor Protein
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Concept
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Mitogen-Activated Protein Kinase Phosphatases
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Concept
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Protein Engineering
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Academic Article
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The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
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Academic Article
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Induction of differentiation and c-jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases.
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Academic Article
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The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.
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Academic Article
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Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.
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Academic Article
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases.
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Academic Article
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Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset.
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Academic Article
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PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
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Academic Article
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Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
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Academic Article
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Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy.
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Academic Article
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PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.
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Academic Article
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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase.
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Academic Article
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PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth.
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Academic Article
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PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
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Concept
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Myeloid Cell Leukemia Sequence 1 Protein
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Concept
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S100 Calcium Binding Protein beta Subunit
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Concept
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Myotonin-Protein Kinase
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Concept
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Enhancer of Zeste Homolog 2 Protein
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Concept
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Nanog Homeobox Protein
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Concept
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Concept
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X-Box Binding Protein 1
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Concept
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Bcl-2-Like Protein 11
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Academic Article
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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer.
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Academic Article
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Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors.
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Academic Article
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An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells.
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